Sodium Hydroxide → HCID 17795734, compound

HRID 1859877Notes

Reaction equation

HRID 1859877 reaction equation
[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22]([C:24]2[CH:25]=[CH:26][C:27]([O:30][CH:31]([CH3:33])[CH3:32])=[N:28][CH:29]=2)=[O:23])=[CH:14][CH:13]=1)[C:6]([O:8]CC)=[O:7])[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>>[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22]([C:24]2[CH:25]=[CH:26][C:27]([O:30][CH:31]([CH3:32])[CH3:33])=[N:28][CH:29]=2)=[O:23])=[CH:14][CH:13]=1)[C:6]([OH:8])=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18625961HCID 18625961, compound

Product 1

HCID 17795734HCID 17795734, compoundYield 85.9%

Procedure

In a similar manner to that described in Example 2, ethyl 2-butyl-3-[4-[2-(2-isopropoxypyridine-5-carbonylamino)ethoxy]phenyl]propionate (170 mg), which is the product of Example 53, was reacted with aqueous sodium hydroxide solution (1N, 0.75 ml) and the reaction mixture was treated to give the title compound (137 mg) as colorless crystals.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-5b5c5203e70e4d21866e931de4e5ce11
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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