Sodium Hydroxide → HCID 17795786, compound

HRID 1859879Notes

Reaction equation

HRID 1859879 reaction equation
[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22]([C:24]2[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[NH:26][CH:25]=2)=[O:23])=[CH:14][CH:13]=1)[C:6]([O:8]CC)=[O:7])[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>>[CH2:1]([CH:5]([CH2:11][C:12]1[CH:13]=[CH:14][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22]([C:24]2[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[NH:26][CH:25]=2)=[O:23])=[CH:16][CH:17]=1)[C:6]([OH:8])=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18625726HCID 18625726, compound

Product 1

HCID 17795786HCID 17795786, compoundYield 82.2%

Procedure

In a similar manner to that described in Example 2, ethyl 2-butyl-3-[4-[2-(indole-3-carbonylamino)ethoxy]phenyl]propionate (650 mg), which is the product of Example 59, was reacted with aqueous sodium hydroxide solution (1N, 5.00 ml) and the reaction mixture was treated to give the title compound (500 mg) as a white powder.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-5892516717c14fa88c205a6f41d44165
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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