Sodium Hydroxide → HCID 17795720, compound

HRID 1859880Notes

Reaction equation

[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22](=[O:35])[C:23]2[CH:28]=[CH:27][C:26]([N:29]3[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]3)=[CH:25][CH:24]=2)=[CH:14][CH:13]=1)[C:6]([O:8]CC)=[O:7])[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>>[CH2:1]([CH:5]([CH2:11][C:12]1[CH:13]=[CH:14][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22](=[O:35])[C:23]2[CH:28]=[CH:27][C:26]([N:29]3[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]3)=[CH:25][CH:24]=2)=[CH:16][CH:17]=1)[C:6]([OH:8])=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 18625928HCID 18625928, compound

Product 1

HCID 17795720HCID 17795720, compoundYield 93%

Procedure

In a similar manner to that described in Example 2, ethyl 2-butyl-3-[4-[2-(4-piperidine-1-ylbenzoylamino)ethoxy]phenyl]propionate (370 mg), which is the product of Example 63, was reacted with aqueous sodium hydroxide solution (1N, 2.30 ml) and the reaction mixture was treated to give the title compound (324 mg) as a white powder.

Workup

additionthe reaction mixture was treated

Sources & evidence

ORD record: ord-d5cf25c12dc24a1da6c9271f3f8e3788
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06528525B1

Reaction notes

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