Sodium Hydroxide → 2-Butyl-3-[4-[3-(4-pyridine-2-ylbenzoylamino)propoxy]phenyl]propionic acid

HRID 1859881Notes

Reaction equation

HRID 1859881 reaction equation
[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][NH:22][C:23](=[O:36])[C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=3)=[CH:26][CH:25]=2)=[CH:14][CH:13]=1)[C:6]([O:8]CC)=[O:7])[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>>[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][NH:22][C:23](=[O:36])[C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=3)=[CH:26][CH:25]=2)=[CH:14][CH:13]=1)[C:6]([OH:8])=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18626012Ethyl 2-butyl-3-[4-[3-(4-pyridine-2-ylbenzoylamino)propoxy]phenyl]propionate

Product 1

HCID 99817062-Butyl-3-[4-[3-(4-pyridine-2-ylbenzoylamino)propoxy]phenyl]propionic acidYield 77.1%

Procedure

In a similar manner to that described in Example 2, ethyl 2-butyl-3-[4-[3-(4-pyridine-2-ylbenzoylamino)propoxy]phenyl]propionate (161 mg), which is the product of Example 69, was reacted with aqueous sodium hydroxide solution (1N, 1.20 ml) and the reaction mixture was treated to give the title compound (117 mg) as a white powder.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-781583326a514a719623b541cdccc6de
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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