Sodium Hydroxide → HCID 18625881, compound

HRID 1859882Notes

Reaction equation

HRID 1859882 reaction equation
[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][N:22]([C:24](=[O:37])[C:25]2[CH:30]=[CH:29][C:28]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][N:32]=3)=[CH:27][CH:26]=2)[CH3:23])=[CH:14][CH:13]=1)[C:6]([O:8]CC)=[O:7])[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>>[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][N:22]([C:24](=[O:37])[C:25]2[CH:30]=[CH:29][C:28]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][N:32]=3)=[CH:27][CH:26]=2)[CH3:23])=[CH:14][CH:13]=1)[C:6]([OH:8])=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18625975HCID 18625975, compound

Product 1

HCID 18625881HCID 18625881, compoundYield 67.3%

Procedure

In a similar manner to that described in Example 2, ethyl 2-butyl-3-[4-[3-[N-methyl-(4-pyridine-2-ylbenzoyl)amino]propoxy]phenyl]propionate (200 mg). which is the product of Example 71, was reacted with aqueous sodium hydroxide solution (1N, 1.20 ml) and the reaction mixture was treated to give the title compound (127 mg) as a white powder.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-91660f1f410c4eabb5aae47e6d2da493
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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