Sodium Hydroxide → HCID 10048438, compound

HRID 1859884Notes

Reaction equation

[CH2:1]([CH:4]([CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][NH:20][C:21](=[O:34])[C:22]2[CH:27]=[CH:26][C:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=3)=[CH:24][CH:23]=2)=[CH:13][CH:12]=1)[C:5]([O:7]CC)=[O:6])[CH2:2][CH3:3].[OH-].[Na+]>>[CH2:1]([CH:4]([CH2:10][C:11]1[CH:12]=[CH:13][C:14]([O:17][CH2:18][CH2:19][NH:20][C:21](=[O:34])[C:22]2[CH:23]=[CH:24][C:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=3)=[CH:26][CH:27]=2)=[CH:15][CH:16]=1)[C:5]([OH:7])=[O:6])[CH2:2][CH3:3]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 18625747HCID 18625747, compound

Product 1

HCID 10048438HCID 10048438, compoundYield 99.4%

Procedure

In a similar manner to that described in Example 2, ethyl 2-propyl-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate (2.10 g), which is the product of Example 73, was reacted with aqueous sodium hydroxide solution (1N, 15.0 ml) and the reaction mixture was treated to give the title compound (1.96 g) as a white powder.

Workup

additionthe reaction mixture was treated

Sources & evidence

ORD record: ord-8b75ce28f4e94ae39ea5a8efa30c0dc2
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06528525B1

Reaction notes

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