Sodium Hydroxide → HCID 10323675, compound

HRID 1859887Notes

Reaction equation

HRID 1859887 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([NH:16][CH2:17][CH2:18][O:19][C:20]3[CH:25]=[CH:24][C:23]([CH2:26][CH:27]([O:33][C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)[C:28]([O:30]CC)=[O:29])=[CH:22][CH:21]=3)=[O:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[OH-].[Na+]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([NH:16][CH2:17][CH2:18][O:19][C:20]3[CH:25]=[CH:24][C:23]([CH2:26][CH:27]([O:33][C:34]4[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=4)[C:28]([OH:30])=[O:29])=[CH:22][CH:21]=3)=[O:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18625753HCID 18625753, compound

Product 1

HCID 10323675HCID 10323675, compoundYield 100%

Procedure

In a similar manner to that described in Example 2, ethyl 3-[4-[2-(4′-fluorobiphenyl-4-carbonylamino)ethoxy]phenyl]-2-phenoxypropionate (915 mg), which is the product of Example 77, was reacted with aqueous sodium hydroxide solution (1N, 5.00 ml) and the reaction mixture was treated to give the title compound (866 mg) as a white powder.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-741ed66e8ab341c8bfb6ef8958028215
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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