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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1859888Generated: November 3, 2026

Sodium Hydroxide → 3-[4-[2-(4'-Chlorobiphenyl-4-carbonylamino)ethoxy]phenyl]-2-phenoxypropionic acid

https://huagongshe.com/reaction/1859888

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium HydroxideHCID 14798—
ReactantEthyl 3-[4-[2-(4'-chlorobiphenyl-4-carbonylamino)ethoxy]phenyl]-2-phenoxypropionateHCID 18626003—
Product3-[4-[2-(4'-Chlorobiphenyl-4-carbonylamino)ethoxy]phenyl]-2-phenoxypropionic acidHCID 1025596274.7%

Reaction Steps

In a similar manner to that described in Example 2, ethyl 3-[4-[2-(4′-chlorobiphenyl-4-carbonylamino)ethoxy]phenyl]-2-phenoxypropionate (900 mg), which is the product of Example 79, was reacted with aqueous sodium hydroxide solution (1N, 5.00 ml) and the reaction mixture was treated to give the title compound (638 mg) as a white powder.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06528525B1
Source datasetuspto-grants-2003_03
ORD IDord-9b100e05334242c1b4674948685711dd
Source noteuspto-grants-2003_03