Sodium Hydroxide → HCID 10347504, compound

HRID 1859889Notes

Reaction equation

[F:1][C:2]([F:42])([F:41])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([NH:17][CH2:18][CH2:19][O:20][C:21]3[CH:26]=[CH:25][C:24]([CH2:27][CH:28]([O:34][C:35]4[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=4)[C:29]([O:31]CC)=[O:30])=[CH:23][CH:22]=3)=[O:16])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.[OH-].[Na+]>>[F:1][C:2]([F:41])([F:42])[C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:10]=[CH:11][C:12]([C:15]([NH:17][CH2:18][CH2:19][O:20][C:21]3[CH:26]=[CH:25][C:24]([CH2:27][CH:28]([O:34][C:35]4[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=4)[C:29]([OH:31])=[O:30])=[CH:23][CH:22]=3)=[O:16])=[CH:13][CH:14]=2)=[CH:7][CH:8]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 18625945HCID 18625945, compound

Product 1

HCID 10347504HCID 10347504, compoundYield 81.2%

Procedure

In a similar manner to that described in Example 2, ethyl 3-[4-[2-(4′-trifluoromethylbiphenyl-4-carbonylamino)ethoxy]phenyl]-2-phenoxypropionate (1.10 g), which is the product of Example 81, was reacted with aqueous sodium hydroxide solution (1N, 5.00 ml) and the reaction mixture was treated to give the title compound (850 mg) as a white powder.

Workup

additionthe reaction mixture was treated

Sources & evidence

ORD record: ord-730956292ddb4ede828bca942ea370a5
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06528525B1

Reaction notes

Loading…