Sodium Hydroxide → HCID 18625884, compound

HRID 1859890Notes

Reaction equation

HRID 1859890 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([NH:11][CH2:12][CH2:13][O:14][C:15]2[CH:20]=[CH:19][C:18]([CH2:21][CH:22]([O:28][C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:23]([O:25]CC)=[O:24])=[CH:17][CH:16]=2)=[O:10])=[CH:5][N:4]=1.[OH-].[Na+]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([NH:11][CH2:12][CH2:13][O:14][C:15]2[CH:20]=[CH:19][C:18]([CH2:21][CH:22]([O:28][C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:23]([OH:25])=[O:24])=[CH:17][CH:16]=2)=[O:10])=[CH:5][N:4]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18625957HCID 18625957, compound

Product 1

HCID 18625884HCID 18625884, compoundYield 83.9%

Procedure

In a similar manner to that described in Example 2, ethyl 3-[4-[2-(2-methoxypyridine-5-carbonylamino)ethoxy]phenyl]-2-phenoxypropionate (330 mg), which is the product of Example 84, was reacted with aqueous sodium hydroxide solution (1N, 2.50 ml) and the reaction mixture was treated to give the title compound (260 mg) as colorless crystals.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-f3e3e537e13f461b9ee82666f5c5224f
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

Loading…