Sodium Hydroxide → HCID 18625997, compound

HRID 1859894Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([NH:16][CH2:17][CH2:18][O:19][C:20]3[CH:25]=[CH:24][C:23]([CH2:26][CH:27]([O:33][C:34]4[CH:39]=[CH:38][C:37]([CH:40]([CH3:42])[CH3:41])=[CH:36][CH:35]=4)[C:28]([O:30]CC)=[O:29])=[CH:22][CH:21]=3)=[O:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[OH-].[Na+]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([NH:16][CH2:17][CH2:18][O:19][C:20]3[CH:25]=[CH:24][C:23]([CH2:26][CH:27]([O:33][C:34]4[CH:35]=[CH:36][C:37]([CH:40]([CH3:42])[CH3:41])=[CH:38][CH:39]=4)[C:28]([OH:30])=[O:29])=[CH:22][CH:21]=3)=[O:15])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 18625746HCID 18625746, compound

Product 1

HCID 18625997HCID 18625997, compoundYield 88.8%

Procedure

In a similar manner to that described in Example 2, ethyl 3-[4-[2-(4′-fluorobiphenyl-4-carbonylamino)ethoxy]phenyl]-2-(4-isopropylphenoxy)propionate (450 mg), which is the product of Example 90, was reacted with aqueous sodium hydroxide solution (1N, 2.00 ml) and the reaction mixture was treated to give the title compound (380 mg) as a white powder.

Workup

additionthe reaction mixture was treated

Sources & evidence

ORD record: ord-d545cab28509476b958bd7afe95496e9
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06528525B1

Reaction notes

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