Sodium Hydroxide → HCID 23694240, compound

HRID 1859896Notes

Reaction equation

[CH:1]([C:4]1[CH:43]=[CH:42][C:7]([O:8][CH:9]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][NH:25][C:26]([C:28]3[CH:33]=[CH:32][C:31]([C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=4[O:40][CH3:41])=[CH:30][CH:29]=3)=[O:27])=[CH:18][CH:17]=2)[C:10]([O:12]CC)=[O:11])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[OH-].[Na+:45]>>[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([O:8][CH:9]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][NH:25][C:26]([C:28]3[CH:29]=[CH:30][C:31]([C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=4[O:40][CH3:41])=[CH:32][CH:33]=3)=[O:27])=[CH:18][CH:17]=2)[C:10]([O-:12])=[O:11])=[CH:42][CH:43]=1)([CH3:3])[CH3:2].[Na+:45]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 18625916HCID 18625916, compound

Product 1

HCID 23694240HCID 23694240, compound

Procedure

In a similar manner to that described in Example 2, ethyl 2-(4-isopropylphenoxy)-3-[4-[2-(2′-methoxybiphenyl-4-carbonylamino)ethoxy]phenyl]propionate (700 mg), which is the product of Example 94, was reacted with aqueous sodium hydroxide solution (1N, 3.60 ml) and the reaction mixture was treated to give the title compound (528 mg) as a white powder.

Workup

additionthe reaction mixture was treated

Sources & evidence

ORD record: ord-942126c1c4124b98a02fa15628d52d41
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06528525B1

Reaction notes

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