Sodium Hydroxide → HCID 11756564, compound

HRID 1859897Notes

Reaction equation

HRID 1859897 reaction equation
[CH:1]([C:4]1[CH:41]=[CH:40][C:7]([O:8][CH:9]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][NH:25][C:26]([C:28]3[CH:29]=[CH:30][C:31]([C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)=[N:32][CH:33]=3)=[O:27])=[CH:18][CH:17]=2)[C:10]([O:12]CC)=[O:11])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[OH-].[Na+]>>[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([O:8][CH:9]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][NH:25][C:26]([C:28]3[CH:29]=[CH:30][C:31]([C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)=[N:32][CH:33]=3)=[O:27])=[CH:18][CH:17]=2)[C:10]([OH:12])=[O:11])=[CH:40][CH:41]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18625732HCID 18625732, compound

Product 1

HCID 11756564HCID 11756564, compoundYield 78.5%

Procedure

In a similar manner to that described in Example 2, ethyl 2-(4-isopropylphenoxy)-3-[4-[2-(2-phenylpyridine-5-carbonylamino)ethoxy]phenyl]propionate (169 mg), which is the product of Example 96, was reacted with aqueous sodium hydroxide solution (1N, 0.60 ml) and the reaction mixture was treated to give the title compound (126 mg) as colorless crystals.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-fb4021bb83ef4866b83d84cdae93477a
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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