Sodium Hydroxide → HCID 23694242, compound

HRID 1859900Notes

Reaction equation

[F:1][C:2]([F:43])([CH:40]([F:42])[F:41])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]([NH:13][CH2:14][CH2:15][O:16][C:17]2[CH:22]=[CH:21][C:20]([CH2:23][CH:24]([O:30][C:31]3[CH:36]=[CH:35][C:34]([CH:37]([CH3:39])[CH3:38])=[CH:33][CH:32]=3)[C:25]([O:27]CC)=[O:26])=[CH:19][CH:18]=2)=[O:12])=[CH:7][N:6]=1.[OH-].[Na+:45]>>[F:43][C:2]([F:1])([CH:40]([F:41])[F:42])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]([NH:13][CH2:14][CH2:15][O:16][C:17]2[CH:18]=[CH:19][C:20]([CH2:23][CH:24]([O:30][C:31]3[CH:36]=[CH:35][C:34]([CH:37]([CH3:38])[CH3:39])=[CH:33][CH:32]=3)[C:25]([O-:27])=[O:26])=[CH:21][CH:22]=2)=[O:12])=[CH:7][N:6]=1.[Na+:45]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 18625728HCID 18625728, compound

Product 1

HCID 23694242HCID 23694242, compound

Procedure

In a similar manner to that described in Example 2, ethyl 3-[4-[2-[2-(2,2,3,3-tetrafluoropropoxy)pyridine-5-carbonylamino]ethoxy]phenyl]-2-(4-isopropylphenoxy)propionate (73 mg), which is the product of Example 102, was reacted with aqueous sodium hydroxide solution (1N, 0.13 ml) and the reaction mixture was treated to give the title compound (51 mg) as colorless crystals.

Workup

additionthe reaction mixture was treated

Sources & evidence

ORD record: ord-c202aba8619644788385a2d46851f7ca
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06528525B1

Reaction notes

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