Sodium Hydroxide → HCID 10053729, compound

HRID 1859901Notes

Reaction equation

[CH:1]([C:4]1[CH:44]=[CH:43][C:7]([O:8][CH:9]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][NH:25][C:26](=[O:42])[C:27]3[CH:32]=[CH:31][C:30]([C:33]4[N:38]=[CH:37][C:36]([N+:39]([O-:41])=[O:40])=[CH:35][CH:34]=4)=[CH:29][CH:28]=3)=[CH:18][CH:17]=2)[C:10]([O:12]CC)=[O:11])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[OH-].[Na+]>>[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([O:8][CH:9]([CH2:15][C:16]2[CH:17]=[CH:18][C:19]([O:22][CH2:23][CH2:24][NH:25][C:26](=[O:42])[C:27]3[CH:32]=[CH:31][C:30]([C:33]4[N:38]=[CH:37][C:36]([N+:39]([O-:41])=[O:40])=[CH:35][CH:34]=4)=[CH:29][CH:28]=3)=[CH:20][CH:21]=2)[C:10]([OH:12])=[O:11])=[CH:43][CH:44]=1)([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 18625850HCID 18625850, compound

Product 1

HCID 10053729HCID 10053729, compoundYield 57.1%

Procedure

In a similar manner to that described in Example 2, ethyl 2-(4-isopropylphenoxy)-3-[4-[2-[4-(3-nitropyridine-6-yl)benzoylamino]ethoxy]phenyl]propionate (397 mg), which is the product of Example 108, was reacted with aqueous sodium hydroxide solution (1N, 1.30 ml) and the reaction mixture was treated to give the title compound (216 mg) as a white powder.

Workup

additionthe reaction mixture was treated

Sources & evidence

ORD record: ord-914feefc40024b8c828a61a594f714a0
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06528525B1

Reaction notes

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