Sodium Hydroxide → HCID 9829103, compound

HRID 1859902Notes

Reaction equation

[CH:1]([C:4]1[CH:43]=[CH:42][C:7]([O:8][CH:9]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][NH:25][C:26](=[O:41])[C:27]3[CH:32]=[CH:31][C:30]([C:33]4[N:38]=[CH:37][C:36]([O:39][CH3:40])=[CH:35][CH:34]=4)=[CH:29][CH:28]=3)=[CH:18][CH:17]=2)[C:10]([O:12]CC)=[O:11])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[OH-].[Na+]>>[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([O:8][CH:9]([CH2:15][C:16]2[CH:17]=[CH:18][C:19]([O:22][CH2:23][CH2:24][NH:25][C:26](=[O:41])[C:27]3[CH:32]=[CH:31][C:30]([C:33]4[N:38]=[CH:37][C:36]([O:39][CH3:40])=[CH:35][CH:34]=4)=[CH:29][CH:28]=3)=[CH:20][CH:21]=2)[C:10]([OH:12])=[O:11])=[CH:42][CH:43]=1)([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 18625864HCID 18625864, compound

Product 1

HCID 9829103HCID 9829103, compoundYield 92.6%

Procedure

In a similar manner to that described in Example 2, ethyl 2-(4-isopropylphenoxy)-3-[4-[2-[4-(3-methoxypyridine-6-yl)benzoylamino]ethoxy]phenyl]propionate (210 mg), which is the product of Example 110, was reacted with aqueous sodium hydroxide solution (1N, 0.72 ml) and the reaction mixture was treated to give the title compound (185 mg) as a white powder.

Workup

additionthe reaction mixture was treated

Sources & evidence

ORD record: ord-b64247786ddf4efbacbca729665a9c15
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06528525B1

Reaction notes

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