Sodium Hydroxide → HCID 10099483, compound

HRID 1859903Notes

Reaction equation

[CH3:1][N:2]([CH3:44])[C:3]1[CH:4]=[N:5][C:6]([C:9]2[CH:43]=[CH:42][C:12]([C:13]([NH:15][CH2:16][CH2:17][O:18][C:19]3[CH:24]=[CH:23][C:22]([CH2:25][CH:26]([O:32][C:33]4[CH:38]=[CH:37][C:36]([CH:39]([CH3:41])[CH3:40])=[CH:35][CH:34]=4)[C:27]([O:29]CC)=[O:28])=[CH:21][CH:20]=3)=[O:14])=[CH:11][CH:10]=2)=[CH:7][CH:8]=1.[OH-].[Na+]>>[CH3:44][N:2]([CH3:1])[C:3]1[CH:4]=[N:5][C:6]([C:9]2[CH:10]=[CH:11][C:12]([C:13]([NH:15][CH2:16][CH2:17][O:18][C:19]3[CH:24]=[CH:23][C:22]([CH2:25][CH:26]([O:32][C:33]4[CH:34]=[CH:35][C:36]([CH:39]([CH3:41])[CH3:40])=[CH:37][CH:38]=4)[C:27]([OH:29])=[O:28])=[CH:21][CH:20]=3)=[O:14])=[CH:42][CH:43]=2)=[CH:7][CH:8]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 18625873HCID 18625873, compound

Product 1

HCID 10099483HCID 10099483, compoundYield 53.6%

Procedure

In a similar manner to that described in Example 2, ethyl 3-[4-[2-[4-(3-dimethylaminopyridine-6-yl)benzoylamino]ethoxy]-phenyl]-2-(4-isopropylphenoxy)propionate (429 mg), which is the product of Example 112, was reacted with aqueous sodium hydroxide solution (1N, 1.44 ml) and the reaction mixture was treated to give the title compound (219 mg) as a white powder.

Workup

additionthe reaction mixture was treated

Sources & evidence

ORD record: ord-deaedf7d12a1419782c21d25c9142970
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06528525B1

Reaction notes

Loading…