Sodium Hydroxide → HCID 10006017, compound

HRID 1859904Notes

Reaction equation

HRID 1859904 reaction equation
[CH3:1][C:2]1[CH:39]=[CH:38][C:5]([O:6][CH:7]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][NH:23][C:24](=[O:37])[C:25]3[CH:30]=[CH:29][C:28]([C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][N:32]=4)=[CH:27][CH:26]=3)=[CH:16][CH:15]=2)[C:8]([O:10]CC)=[O:9])=[CH:4][CH:3]=1.[OH-].[Na+]>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH:7]([CH2:13][C:14]2[CH:15]=[CH:16][C:17]([O:20][CH2:21][CH2:22][NH:23][C:24](=[O:37])[C:25]3[CH:30]=[CH:29][C:28]([C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][N:32]=4)=[CH:27][CH:26]=3)=[CH:18][CH:19]=2)[C:8]([OH:10])=[O:9])=[CH:38][CH:39]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18625737HCID 18625737, compound

Product 1

HCID 10006017HCID 10006017, compoundYield 88.6%

Procedure

In a similar manner to that described in Example 2, ethyl 2-(4-methylphenoxy)-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate (680 mg), which is the product of Example 114, was reacted with aqueous sodium hydroxide solution (1N, 2.60 ml) and the reaction mixture was treated to give the title compound (570 mg) as a white powder.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-00b41396d3aa48989db236123f4a1f40
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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