Sodium Hydroxide → HCID 10007427, compound

HRID 1859905Notes

Reaction equation

[C:1]([C:5]1[CH:42]=[CH:41][C:8]([O:9][CH:10]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][CH2:24][CH2:25][NH:26][C:27](=[O:40])[C:28]3[CH:33]=[CH:32][C:31]([C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][N:35]=4)=[CH:30][CH:29]=3)=[CH:19][CH:18]=2)[C:11]([O:13]CC)=[O:12])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+]>>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([O:9][CH:10]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][CH2:24][CH2:25][NH:26][C:27](=[O:40])[C:28]3[CH:29]=[CH:30][C:31]([C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][N:35]=4)=[CH:32][CH:33]=3)=[CH:19][CH:18]=2)[C:11]([OH:13])=[O:12])=[CH:41][CH:42]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 18625917HCID 18625917, compound

Product 1

HCID 10007427HCID 10007427, compoundYield 92.1%

Procedure

In a similar manner to that described in Example 2, ethyl 2-(4-t-butylphenoxy)-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate (360 mg), which is the product of Example 116, was reacted with aqueous sodium hydroxide solution (1N, 2.00 ml) and the reaction mixture was treated to give the title compound (315 mg) as a white powder.

Workup

additionthe reaction mixture was treated

Sources & evidence

ORD record: ord-cad0d2b479ab45e9a26e2babb5e9aa02
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06528525B1

Reaction notes

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