Sodium Hydroxide → HCID 10391849, compound

HRID 1859907Notes

Reaction equation

[Cl:1][C:2]1[CH:39]=[CH:38][C:5]([O:6][CH:7]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][NH:23][C:24](=[O:37])[C:25]3[CH:30]=[CH:29][C:28]([C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][N:32]=4)=[CH:27][CH:26]=3)=[CH:16][CH:15]=2)[C:8]([O:10]CC)=[O:9])=[CH:4][CH:3]=1.[OH-].[Na+]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH:7]([CH2:13][C:14]2[CH:15]=[CH:16][C:17]([O:20][CH2:21][CH2:22][NH:23][C:24](=[O:37])[C:25]3[CH:30]=[CH:29][C:28]([C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][N:32]=4)=[CH:27][CH:26]=3)=[CH:18][CH:19]=2)[C:8]([OH:10])=[O:9])=[CH:38][CH:39]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 18625852HCID 18625852, compound

Product 1

HCID 10391849HCID 10391849, compoundYield 92.6%

Procedure

In a similar manner to that described in Example 2, ethyl 2-(4-chlorophenoxy)-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate (950 mg), which is the product of Example 120, was reacted with aqueous sodium hydroxide solution (1N, 3.49 ml) and the reaction mixture was treated to give the title compound (834 mg) as colorless crystals.

Workup

additionthe reaction mixture was treated

Sources & evidence

ORD record: ord-169e35df668d4d3ba1e1046913f0e7a3
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06528525B1

Reaction notes

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