Sodium Hydroxide → HCID 10099056, compound

HRID 1859908Notes

Reaction equation

HRID 1859908 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:42]=[CH:41][C:10]([C:11]([NH:13][CH2:14][CH2:15][O:16][C:17]2[CH:22]=[CH:21][C:20]([CH2:23][CH:24]([O:30][C:31]3[CH:36]=[CH:35][C:34]([C:37]([F:40])([F:39])[F:38])=[CH:33][CH:32]=3)[C:25]([O:27]CC)=[O:26])=[CH:19][CH:18]=2)=[O:12])=[CH:9][CH:8]=1.[OH-].[Na+]>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:42]=[CH:41][C:10]([C:11]([NH:13][CH2:14][CH2:15][O:16][C:17]2[CH:22]=[CH:21][C:20]([CH2:23][CH:24]([O:30][C:31]3[CH:32]=[CH:33][C:34]([C:37]([F:38])([F:39])[F:40])=[CH:35][CH:36]=3)[C:25]([OH:27])=[O:26])=[CH:19][CH:18]=2)=[O:12])=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18625826HCID 18625826, compound

Product 1

HCID 10099056HCID 10099056, compoundYield 53.9%

Procedure

In a similar manner to that described in Example 2, ethyl 3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]-2-(4-trifluoromethylphenoxy)propionate (269 mg), which is the product of Example 122, was reacted with aqueous sodium hydroxide solution (1N, 0.55 ml) and the reaction mixture was treated to give the title compound (138 mg) as a white powder.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-6303a47fa6c64d1188d35e611405a1de
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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