Sodium Hydroxide → HCID 10099467, compound

HRID 1859910Notes

Reaction equation

[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:43]=[CH:42][C:10]([C:11]([NH:13][CH2:14][CH2:15][O:16][C:17]2[CH:22]=[CH:21][C:20]([CH2:23][CH:24]([O:30][C:31]3[CH:36]=[CH:35][C:34]([O:37][C:38]([F:41])([F:40])[F:39])=[CH:33][CH:32]=3)[C:25]([O:27]CC)=[O:26])=[CH:19][CH:18]=2)=[O:12])=[CH:9][CH:8]=1.[OH-].[Na+]>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:43]=[CH:42][C:10]([C:11]([NH:13][CH2:14][CH2:15][O:16][C:17]2[CH:18]=[CH:19][C:20]([CH2:23][CH:24]([O:30][C:31]3[CH:32]=[CH:33][C:34]([O:37][C:38]([F:39])([F:40])[F:41])=[CH:35][CH:36]=3)[C:25]([OH:27])=[O:26])=[CH:21][CH:22]=2)=[O:12])=[CH:9][CH:8]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 18625887HCID 18625887, compound

Product 1

HCID 10099467HCID 10099467, compoundYield 84.6%

Procedure

In a similar manner to that described in Example 2, ethyl 3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]-2-(4-trifluoromethoxyphenoxy)propionate (1.65 g), which is the product of Example 126, was reacted with aqueous sodium hydroxide solution (1N, 5.54 ml) and the reaction mixture was treated to give the title compound (1.33 g) as colorless crystals.

Workup

additionthe reaction mixture was treated

Sources & evidence

ORD record: ord-2c43c984c2e447ed91c77544eda5f510
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06528525B1

Reaction notes

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