Sodium Hydroxide → HCID 17795615, compound

HRID 1859911Notes

Reaction equation

HRID 1859911 reaction equation
[C:1]([C:3]1[CH:40]=[CH:39][C:6]([O:7][CH:8]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][CH2:22][CH2:23][NH:24][C:25](=[O:38])[C:26]3[CH:31]=[CH:30][C:29]([C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][N:33]=4)=[CH:28][CH:27]=3)=[CH:17][CH:16]=2)[C:9]([O:11]CC)=[O:10])=[CH:5][CH:4]=1)#[N:2].[OH-].[Na+]>>[C:1]([C:3]1[CH:40]=[CH:39][C:6]([O:7][CH:8]([CH2:14][C:15]2[CH:16]=[CH:17][C:18]([O:21][CH2:22][CH2:23][NH:24][C:25](=[O:38])[C:26]3[CH:31]=[CH:30][C:29]([C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][N:33]=4)=[CH:28][CH:27]=3)=[CH:19][CH:20]=2)[C:9]([OH:11])=[O:10])=[CH:5][CH:4]=1)#[N:2]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18625960HCID 18625960, compound

Product 1

HCID 17795615HCID 17795615, compoundYield 79.6%

Procedure

In a similar manner to that described in Example 2, ethyl 2-(4-cyanophenoxy)-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate (244 mg), which is the product of Example 128, was reacted with aqueous sodium hydroxide solution (1N, 0.92 ml) and the reaction mixture was treated to give the title compound (184 mg) as colorless crystals.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-ec7fda45424a4cca9fb2fda97ccf3bda
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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