Sodium Hydroxide → HCID 131723785, compound

HRID 1859912Notes

Reaction equation

HRID 1859912 reaction equation
[CH3:1][C:2]1[CH:38]=[CH:37][C:5]([S:6][CH:7]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][NH:22][C:23](=[O:36])[C:24]3[CH:29]=[CH:28][C:27]([C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=4)=[CH:26][CH:25]=3)=[CH:15][CH:14]=2)[C:8]([O:10]C)=[O:9])=[CH:4][CH:3]=1.[OH-].[Na+]>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([S:6][CH:7]([CH2:12][C:13]2[CH:14]=[CH:15][C:16]([O:19][CH2:20][CH2:21][NH:22][C:23](=[O:36])[C:24]3[CH:29]=[CH:28][C:27]([C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=4)=[CH:26][CH:25]=3)=[CH:17][CH:18]=2)[C:8]([OH:10])=[O:9])=[CH:37][CH:38]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 131723786HCID 131723786, compound

Product 1

HCID 131723785HCID 131723785, compoundYield 77.4%

Procedure

In a similar manner to that described in Example 2, methyl 2-(4-methylthiophenoxy)-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate (203 mg), which is the product of Example 130, was reacted with aqueous sodium hydroxide solution (1N, 0.74 ml) and the reaction mixture was treated to give the title compound (153 mg) as colorless crystals.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-9f99c5d3f318462a9421b10b8defc309
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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