Sodium Hydroxide → 2-(4-Pyridine-2-ylphenoxy)-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionic acid

HRID 1859913Notes

Reaction equation

[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:44]=[CH:43][C:10]([O:11][CH:12]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([O:25][CH2:26][CH2:27][NH:28][C:29](=[O:42])[C:30]3[CH:35]=[CH:34][C:33]([C:36]4[CH:41]=[CH:40][CH:39]=[CH:38][N:37]=4)=[CH:32][CH:31]=3)=[CH:21][CH:20]=2)[C:13]([O:15]CC)=[O:14])=[CH:9][CH:8]=1.[OH-].[Na+]>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[CH:9][C:10]([O:11][CH:12]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([O:25][CH2:26][CH2:27][NH:28][C:29](=[O:42])[C:30]3[CH:35]=[CH:34][C:33]([C:36]4[CH:41]=[CH:40][CH:39]=[CH:38][N:37]=4)=[CH:32][CH:31]=3)=[CH:21][CH:20]=2)[C:13]([OH:15])=[O:14])=[CH:43][CH:44]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 18625869HCID 18625869, compound

Product 1

HCID 177956632-(4-Pyridine-2-ylphenoxy)-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionic acidYield 81.9%

Procedure

In a similar manner to that described in Example 2, ethyl 2-(4-pyridine-2-ylphenoxy)-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate (500 mg), which is the product of Example 134, was reacted with aqueous sodium hydroxide solution (1N, 2.00 ml) and the reaction mixture was treated to give the title compound (390 mg) as a white powder.

Workup

additionthe reaction mixture was treated

Sources & evidence

ORD record: ord-a5ed063452a64d8283ca7417074e45ab
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06528525B1

Reaction notes

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