Sodium Hydroxide → HCID 10481724, compound

HRID 1859916Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([CH:37]=[CH:38][C:39]=1[F:40])[O:5][CH:6]([CH2:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][NH:22][C:23](=[O:36])[C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=3)=[CH:26][CH:25]=2)=[CH:15][CH:14]=1)[C:7]([O:9]CC)=[O:8].[OH-].[Na+]>>[F:1][C:2]1[CH:3]=[C:4]([CH:37]=[CH:38][C:39]=1[F:40])[O:5][CH:6]([CH2:12][C:13]1[CH:14]=[CH:15][C:16]([O:19][CH2:20][CH2:21][NH:22][C:23](=[O:36])[C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=3)=[CH:26][CH:25]=2)=[CH:17][CH:18]=1)[C:7]([OH:9])=[O:8]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 18625986HCID 18625986, compound

Product 1

HCID 10481724HCID 10481724, compoundYield 92.3%

Procedure

In a similar manner to that described in Example 2, ethyl 2-(3,4-difluorophenoxy)-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate (281 mg), which is the product of Example 140, was reacted with aqueous sodium hydroxide solution (1N, 1.02 ml) and the reaction mixture was treated to give the title compound (246 mg) as a white powder.

Workup

additionthe reaction mixture was treated

Sources & evidence

ORD record: ord-c13cfe1dcb00463ca7e690b27c818eaf
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06528525B1

Reaction notes

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