Sodium Hydroxide → HCID 10098673, compound

HRID 1859917Notes

Reaction equation

HRID 1859917 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:37]=[C:38]([F:41])[C:39]=1[F:40])[O:5][CH:6]([CH2:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][NH:22][C:23](=[O:36])[C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=3)=[CH:26][CH:25]=2)=[CH:15][CH:14]=1)[C:7]([O:9]CC)=[O:8].[OH-].[Na+]>>[F:41][C:38]1[CH:37]=[C:4]([CH:3]=[C:2]([F:1])[C:39]=1[F:40])[O:5][CH:6]([CH2:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][NH:22][C:23](=[O:36])[C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=3)=[CH:26][CH:25]=2)=[CH:15][CH:14]=1)[C:7]([OH:9])=[O:8]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18625898HCID 18625898, compound

Product 1

HCID 10098673HCID 10098673, compoundYield 88.6%

Procedure

In a similar manner to that described in Example 2, ethyl 2-(3,4,5-trifluorophenoxy)-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate (380 mg), which is the product of Example 142, was reacted with aqueous sodium hydroxide solution (1N, 2.00 ml) and the reaction mixture was treated to give the title compound (320 mg) as a white powder.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-8690f2ee3a144653aa8fe8532291678e
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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