Sodium Hydroxide → HCID 18625876, compound

HRID 1859918Notes

Reaction equation

HRID 1859918 reaction equation
[C:1]1([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:6]=[CH:5][C:4]([C:7]([NH:9][CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][C:16]([CH2:19][CH:20]([O:25][C:26]3[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=3)[C:21]([O:23]C)=[O:22])=[CH:15][CH:14]=2)=[O:8])=[CH:3][CH:2]=1.[OH-].[Na+]>>[C:1]1([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:2]=[CH:3][C:4]([C:7]([NH:9][CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][C:16]([CH2:19][CH:20]([O:25][C:26]3[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=3)[C:21]([OH:23])=[O:22])=[CH:15][CH:14]=2)=[O:8])=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18625970HCID 18625970, compound

Product 1

HCID 18625876HCID 18625876, compoundYield 93.1%

Procedure

In a similar manner to that described in Example 2, methyl 3-[4-[2-(biphenyl-4-carbonylamino)ethoxy]phenyl]-2-(4-fluorophenoxy)propionate (266 mg), which is the product of Example 146, was reacted with aqueous sodium hydroxide solution (1N, 1.04 ml) and the reaction mixture was treated to give the title compound (241 mg) as colorless crystals.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-381632547840405ab3efa2a5e3797c25
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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