Sodium Hydroxide → HCID 10030882, compound

HRID 1859919Notes

Reaction equation

[CH:1]([C:4]1[CH:44]=[CH:43][C:7]([O:8][C:9]([CH3:42])([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][NH:25][C:26]([C:28]3[CH:29]=[CH:30][C:31]([C:34]4[CH:39]=[CH:38][C:37]([O:40][CH3:41])=[CH:36][CH:35]=4)=[N:32][CH:33]=3)=[O:27])=[CH:18][CH:17]=2)[C:10]([O:12]CC)=[O:11])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[OH-].[Na+]>>[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([O:8][C:9]([CH3:42])([CH2:15][C:16]2[CH:17]=[CH:18][C:19]([O:22][CH2:23][CH2:24][NH:25][C:26]([C:28]3[CH:29]=[CH:30][C:31]([C:34]4[CH:35]=[CH:36][C:37]([O:40][CH3:41])=[CH:38][CH:39]=4)=[N:32][CH:33]=3)=[O:27])=[CH:20][CH:21]=2)[C:10]([OH:12])=[O:11])=[CH:43][CH:44]=1)([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 18625819HCID 18625819, compound

Product 1

HCID 10030882HCID 10030882, compoundYield 44.3%

Procedure

In a similar manner to that described in Example 2, ethyl 2-(4-isopropylphenoxy)-3-[4-[2-[2-(4-methoxyphenyl)pyridine-5-carbonylamino]ethoxy]phenyl]-2-methylpropionate (341 mg), which is the product of Example 148, was reacted with aqueous sodium hydroxide solution (1N, 1.14 ml) and the reaction mixture was treated to give the title compound (144 mg) as colorless crystals.

Workup

additionthe reaction mixture was treated

Sources & evidence

ORD record: ord-09bd471c2b7842768309da32c30d2cef
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06528525B1

Reaction notes

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