Sodium Hydroxide → HCID 10099979, compound

HRID 1859920Notes

Reaction equation

[F:1][C:2]([F:44])([CH:41]([F:43])[F:42])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]([NH:13][CH2:14][CH2:15][O:16][C:17]2[CH:22]=[CH:21][C:20]([CH2:23][C:24]([O:31][C:32]3[CH:37]=[CH:36][C:35]([CH:38]([CH3:40])[CH3:39])=[CH:34][CH:33]=3)([CH3:30])[C:25]([O:27]CC)=[O:26])=[CH:19][CH:18]=2)=[O:12])=[CH:7][N:6]=1.[OH-].[Na+]>>[F:44][C:2]([F:1])([CH:41]([F:42])[F:43])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]([NH:13][CH2:14][CH2:15][O:16][C:17]2[CH:18]=[CH:19][C:20]([CH2:23][C:24]([O:31][C:32]3[CH:37]=[CH:36][C:35]([CH:38]([CH3:40])[CH3:39])=[CH:34][CH:33]=3)([CH3:30])[C:25]([OH:27])=[O:26])=[CH:21][CH:22]=2)=[O:12])=[CH:7][N:6]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 18625888HCID 18625888, compound

Product 1

HCID 10099979HCID 10099979, compoundYield 69.8%

Procedure

In a similar manner to that described in Example 2, ethyl 3-[4-[2-[2-(2,2,3,3-tetrafluoropropoxy)pyridine-5-carbonylamino]ethoxy]phenyl]-2-(4-isopropylphenoxy)-2-methylpropionate (210 mg), which is the product of Example 150, was reacted with aqueous sodium hydroxide solution (1N, 0.51 ml) and the reaction mixture was treated to give the title compound (140 mg) as colorless crystals.

Workup

additionthe reaction mixture was treated

Sources & evidence

ORD record: ord-d823e495e656465886f889c17fbd7a41
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06528525B1

Reaction notes

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