Sodium Hydroxide → HCID 18625982, compound

HRID 1859921Notes

Reaction equation

[C:1]1([S:7][CH:8]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][NH:23][C:24](=[O:37])[C:25]3[CH:30]=[CH:29][C:28]([C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][N:32]=4)=[CH:27][CH:26]=3)=[CH:16][CH:15]=2)[C:9]([O:11]C)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>>[C:1]1([S:7][CH:8]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][NH:23][C:24](=[O:37])[C:25]3[CH:26]=[CH:27][C:28]([C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][N:32]=4)=[CH:29][CH:30]=3)=[CH:16][CH:15]=2)[C:9]([OH:11])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 18625718HCID 18625718, compound

Product 1

HCID 18625982HCID 18625982, compoundYield 94.6%

Procedure

In a similar manner to that described in Example 2, methyl 2-phenylthio-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate (150 mg), which is the product of Example 152, was reacted with aqueous sodium hydroxide solution (1N, 0.58 ml) and the reaction mixture was treated to give the title compound (138 mg) as colorless crystals.

Workup

additionthe reaction mixture was treated

Sources & evidence

ORD record: ord-4087907394e94150b0c437d8bc4e5f33
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06528525B1

Reaction notes

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