Sodium Hydroxide → HCID 18625903, compound

HRID 1859922Notes

Reaction equation

HRID 1859922 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:37]=[CH:36][C:10]([C:11]([NH:13][CH2:14][CH2:15][O:16][C:17]2[CH:22]=[CH:21][C:20]([CH2:23][CH:24]([O:29][C:30]3[CH:31]=[N:32][CH:33]=[CH:34][CH:35]=3)[C:25]([O:27]C)=[O:26])=[CH:19][CH:18]=2)=[O:12])=[CH:9][CH:8]=1.[OH-].[Na+]>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[CH:9][C:10]([C:11]([NH:13][CH2:14][CH2:15][O:16][C:17]2[CH:22]=[CH:21][C:20]([CH2:23][CH:24]([O:29][C:30]3[CH:31]=[N:32][CH:33]=[CH:34][CH:35]=3)[C:25]([OH:27])=[O:26])=[CH:19][CH:18]=2)=[O:12])=[CH:36][CH:37]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18625794HCID 18625794, compound

Product 1

HCID 18625903HCID 18625903, compoundYield 88%

Procedure

In a similar manner to that described in Example 2, methyl 3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]-2-(pyridine-3-yloxy)propionate (248 mg), which is the product of Example 154, was reacted with aqueous sodium hydroxide solution (1N, 1.00 ml) and the reaction mixture was treated to give the title compound (212 mg) as colorless crystals.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-0a9c850c1882497ab46966c3c52a4eba
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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