Sodium Hydroxide → HCID 17795788, compound

HRID 1859923Notes

Reaction equation

[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[S:10][CH:11]([CH2:16][C:17]1[CH:22]=[CH:21][C:20]([O:23][CH2:24][CH2:25][NH:26][C:27](=[O:40])[C:28]2[CH:33]=[CH:32][C:31]([C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][N:35]=3)=[CH:30][CH:29]=2)=[CH:19][CH:18]=1)[C:12]([O:14]C)=[O:13].[OH-].[Na+]>>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[S:10][CH:11]([CH2:16][C:17]1[CH:18]=[CH:19][C:20]([O:23][CH2:24][CH2:25][NH:26][C:27](=[O:40])[C:28]2[CH:29]=[CH:30][C:31]([C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][N:35]=3)=[CH:32][CH:33]=2)=[CH:21][CH:22]=1)[C:12]([OH:14])=[O:13]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 18625956HCID 18625956, compound

Product 1

HCID 17795788HCID 17795788, compoundYield 70.5%

Procedure

In a similar manner to that described in Example 2, methyl 2-(benzoxazole-2-ylthio)-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate (361 mg), which is the product of Example 156, was reacted with aqueous sodium hydroxide solution (1N, 1.30 ml) and the reaction mixture was treated to give the title compound (248 mg) as colorless crystals.

Workup

additionthe reaction mixture was treated

Sources & evidence

ORD record: ord-c30a05d14f7f4b4eac1206063742648e
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06528525B1

Reaction notes

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