Sodium Hydroxide → HCID 18625851, compound

HRID 1859924Notes

Reaction equation

HRID 1859924 reaction equation
[CH2:1]([O:8][CH:9]([CH2:14][C:15]1[CH:20]=[CH:19][C:18]([O:21][CH2:22][CH2:23][NH:24][C:25](=[O:38])[C:26]2[CH:31]=[CH:30][C:29]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][N:33]=3)=[CH:28][CH:27]=2)=[CH:17][CH:16]=1)[C:10]([O:12]C)=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>>[CH2:1]([O:8][CH:9]([CH2:14][C:15]1[CH:20]=[CH:19][C:18]([O:21][CH2:22][CH2:23][NH:24][C:25](=[O:38])[C:26]2[CH:31]=[CH:30][C:29]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][N:33]=3)=[CH:28][CH:27]=2)=[CH:17][CH:16]=1)[C:10]([OH:12])=[O:11])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18626007HCID 18626007, compound

Product 1

HCID 18625851HCID 18625851, compoundYield 94.1%

Procedure

In a similar manner to that described in Example 2, methyl 2-benzyloxy-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate (94 mg), which is the product of Example 158, was reacted with aqueous sodium hydroxide solution (1N, 0.36 ml) and the reaction mixture was treated to give the title compound (86 mg) as colorless crystals.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-3f13be4cea5b4d3dba4efbe32a9e222b
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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