Sodium Hydroxide → HCID 18625972, compound

HRID 1859925Notes

Reaction equation

HRID 1859925 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:26][CH:27]([O:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[C:28]([O:30]CC)=[O:29])[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][CH2:10][NH:11][C:12](=[O:25])[C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)=[CH:15][CH:14]=1.[OH-].[Na+]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:26][CH:27]([O:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[C:28]([OH:30])=[O:29])[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][CH2:10][NH:11][C:12](=[O:25])[C:13]1[CH:14]=[CH:15][C:16]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18625837HCID 18625837, compound

Product 1

HCID 18625972HCID 18625972, compoundYield 78.9%

Procedure

In a similar manner to that described in Example 2, ethyl 3-[3-chloro-4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]-2-phenoxypropionate (540 mg), which is the product of Example 161, was reacted with aqueous sodium hydroxide solution (1N, 1.98 ml) and the reaction mixture was treated to give the title compound (404 mg) as colorless crystals.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-14de5f16853245789edd73812a754e4b
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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