Sodium Hydroxide → HCID 18626004, compound

HRID 1859926Notes

Reaction equation

HRID 1859926 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:26][CH:27]([O:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[C:28]([O:30]CC)=[O:29])[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][CH2:10][NH:11][C:12](=[O:25])[C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)=[CH:15][CH:14]=1.[OH-].[Na+]>>[Br:1][C:2]1[CH:3]=[C:4]([CH2:26][CH:27]([O:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[C:28]([OH:30])=[O:29])[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][CH2:10][NH:11][C:12](=[O:25])[C:13]1[CH:14]=[CH:15][C:16]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18625788HCID 18625788, compound

Product 1

HCID 18626004HCID 18626004, compoundYield 77.1%

Procedure

In a similar manner to that described in Example 2, ethyl 3-[3-bromo-4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]-2-phenoxypropionate (237 mg), which is the product of Example 163, was reacted with aqueous sodium hydroxide solution (1N, 0.80 ml) and the reaction mixture was treated to give the title compound (174 mg) as colorless crystals.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-5099f37ff0e84bbe941e4894a0fce9a2
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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