Sodium Hydroxide → HCID 18626032, compound

HRID 1859927Notes

Reaction equation

HRID 1859927 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:28][CH:29]([O:35][C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[C:30]([O:32]CC)=[O:31])[CH:7]=[CH:8][C:9]=1[O:10][CH2:11][CH2:12][NH:13][C:14](=[O:27])[C:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=2)=[CH:17][CH:16]=1)([O-:3])=[O:2].[OH-].[Na+]>>[N+:1]([C:4]1[CH:5]=[C:6]([CH2:28][CH:29]([O:35][C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[C:30]([OH:32])=[O:31])[CH:7]=[CH:8][C:9]=1[O:10][CH2:11][CH2:12][NH:13][C:14](=[O:27])[C:15]1[CH:16]=[CH:17][C:18]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=2)=[CH:19][CH:20]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18625798HCID 18625798, compound

Product 1

HCID 18626032HCID 18626032, compoundYield 64.7%

Procedure

In a similar manner to that described in Example 2, ethyl 3-[3-nitro-4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]-2-phenoxypropionate (223 mg), which is the product of Example 165, was reacted with aqueous sodium hydroxide solution (1N, 0.80 ml) and the reaction mixture was treated to give the title compound (137 mg) as colorless crystals.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-19b0683687a946aa92c6b8d05925f9bd
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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