Sodium Hydroxide → HCID 69876561, compound

HRID 1859928Notes

Reaction equation

HRID 1859928 reaction equation
[CH2:1]([O:8][C:9]([NH:11][C@@H:12]([CH2:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH2:26][NH:27][C:28](=[O:41])[C:29]2[CH:34]=[CH:33][C:32]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][N:36]=3)=[CH:31][CH:30]=2)=[CH:20][CH:19]=1)[C:13]([O:15]C)=[O:14])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>>[CH2:1]([O:8][C:9]([NH:11][C@@H:12]([CH2:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH2:26][NH:27][C:28](=[O:41])[C:29]2[CH:34]=[CH:33][C:32]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][N:36]=3)=[CH:31][CH:30]=2)=[CH:20][CH:19]=1)[C:13]([OH:15])=[O:14])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 86590718HCID 86590718, compound

Product 1

HCID 69876561HCID 69876561, compoundYield 73.9%

Procedure

In a similar manner to that described in Example 2, methyl (S)-2-benzyloxycarbonylamino-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate (200 mg), which is the product of Example 167, was reacted with aqueous sodium hydroxide solution (1N, 0.72 ml) and the reaction mixture was treated to give the title compound (144 mg) as a mass of foam.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-aac766328a324f759f0b86ae32b6976a
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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