HCID 86590718, compound → HCID 86590719, compound

Participants

Reaction Steps

In a similar manner to that described in Reference example 1(d), a reaction was carried out using methyl (S)-2-benzyloxycarbonylamino-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate (1.53 g) and palladium on carbon (5%, 150 mg) and the reaction mixture was treated to give methyl (S)-2-amino-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate (1.14 g). Propyl bromide (0.24 ml) and potassium carbonate (387 mg) were added to a solution of the amine derivative (1.12 g) obtained above in N,N-dimethylformamide (10 ml). The mixture was stirred at 70° C. for 16 hours. The reaction mixture was partitioned between ethyl acetate and water and the ethyl acetate layer was separated and dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified via chromatography on a silica gel column using dichloromethane/methanol=19/1 to give the title compound (196 mg) as colorless crystals.

Provenance & Evidence