Sodium Hydroxide → HCID 69875425, compound

HRID 1859930Notes

Reaction equation

[CH2:1]([NH:4][C@@H:5]([CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][NH:20][C:21](=[O:34])[C:22]2[CH:27]=[CH:26][C:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=3)=[CH:24][CH:23]=2)=[CH:13][CH:12]=1)[C:6]([O:8]C)=[O:7])[CH2:2][CH3:3].[OH-].[Na+]>>[CH2:1]([NH:4][C@@H:5]([CH2:10][C:11]1[CH:12]=[CH:13][C:14]([O:17][CH2:18][CH2:19][NH:20][C:21](=[O:34])[C:22]2[CH:23]=[CH:24][C:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=3)=[CH:26][CH:27]=2)=[CH:15][CH:16]=1)[C:6]([OH:8])=[O:7])[CH2:2][CH3:3]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 86590720HCID 86590720, compound

Product 1

HCID 69875425HCID 69875425, compoundYield 87.9%

Procedure

In a similar manner to that described in Example 2, methyl (S)-2-propylamino-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate (169 mg), which is the product of Example 169, was reacted with aqueous sodium hydroxide solution (1N, 0.73 ml) and the reaction mixture was treated to give the title compound (144 mg) as colorless crystals.

Workup

additionthe reaction mixture was treated

Sources & evidence

ORD record: ord-6f3cbaf1caed4e1587ead1f3b0c12acf
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06528525B1

Reaction notes

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