Sodium Hydroxide → HCID 17795736, compound

HRID 1859935Notes

Reaction equation

HRID 1859935 reaction equation
Cl.[CH2:2]([NH:5][CH:6]([CH2:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][NH:22][C:23](=[O:36])[C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=3)=[CH:26][CH:25]=2)=[CH:15][CH:14]=1)[C:7]([O:9]CC)=[O:8])[CH2:3][CH3:4].[OH-].[Na+]>CO>[CH2:2]([NH:5][CH:6]([CH2:12][C:13]1[CH:14]=[CH:15][C:16]([O:19][CH2:20][CH2:21][NH:22][C:23](=[O:36])[C:24]2[CH:25]=[CH:26][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=3)=[CH:28][CH:29]=2)=[CH:17][CH:18]=1)[C:7]([OH:9])=[O:8])[CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18625908HCID 18625908, compound

Product 1

HCID 17795736HCID 17795736, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ethyl 2-propylamino-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate hydrochloride, which is the product of Example 183(b) is hydrolyzed by sodium hydroxide in methanol to give the title compound.

Sources & evidence

ORD record
ord-f5a941af5ca241d49b796c7ef4eec708
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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