Sodium Hydroxide → HCID 18626006, compound

HRID 1859936Notes

Reaction equation

HRID 1859936 reaction equation
Cl.[C:2]1([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH:7]=[CH:6][C:5]([C:8]([NH:10][CH2:11][CH2:12][O:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][CH:21]([NH:27][CH2:28][CH2:29][CH3:30])[C:22]([O:24]CC)=[O:23])=[CH:16][CH:15]=2)=[O:9])=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[C:2]1([C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH:3]=[CH:4][C:5]([C:8]([NH:10][CH2:11][CH2:12][O:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][CH:21]([NH:27][CH2:28][CH2:29][CH3:30])[C:22]([OH:24])=[O:23])=[CH:16][CH:15]=2)=[O:9])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18625978HCID 18625978, compound

Product 1

HCID 18626006HCID 18626006, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ethyl 3-[4-[2-(biphenyl-4-carbonylamino)ethoxy]phenyl]-2-propylaminopropionate hydrochloride, which is the product of Example 185(b), is hydrolyzed by sodium hydroxide in methanol to give the title compound.

Sources & evidence

ORD record
ord-177f454965c94a03b096b12101224be1
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

Loading…