Ethyl 2-(4-benzyloxybenzyl)-5-phenylvalerate → Ethyl 2-(4-hydroxybenzyl)-5-phenylvalerate

HRID 1859945Notes

Reaction equation

HRID 1859945 reaction equation
C([O:8][C:9]1[CH:30]=[CH:29][C:12]([CH2:13][CH:14]([CH2:20][CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:11][CH:10]=1)C1C=CC=CC=1>[Pd]>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:13][CH:14]([CH2:20][CH2:21][CH2:22][C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:29][CH:30]=1

Participants

3

Reactant 1

HCID 18625892Ethyl 2-(4-benzyloxybenzyl)-5-phenylvalerate

Product 1

HCID 18625964Ethyl 2-(4-hydroxybenzyl)-5-phenylvalerateYield 99.4%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

In a similar manner to that described in Reference example 1(d), a reaction was carried out using ethyl 2-(4-benzyloxybenzyl)-5-phenylvalerate (3.32 g) and palladium on carbon (5%, 0.40 g) and the reaction mixture was treated to afford the desired compound (2.56 g) as a syrup.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-e83183d923bb4f80926e016e808e9ae2
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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