HCID 18625812, compound → HCID 18625760, compound

HRID 1859954Notes

Reaction equation

HRID 1859954 reaction equation
[N:1]([CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH:14]([CH2:20][CH2:21][O:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:9][CH:8]=1)=[N+]=[N-]>[Pd]>[NH2:1][CH2:4][CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]([CH2:13][CH:14]([CH2:20][CH2:21][O:22][C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:11][CH:12]=1

Participants

3

Reactant 1

HCID 18625812HCID 18625812, compound

Product 1

HCID 18625760HCID 18625760, compoundYield 94.9%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

In a similar manner to that described in Reference example 1(d), a reaction was carried out using ethyl 3-[4-(2-azidoethoxy)phenyl]-2-(2-phenoxyethyl)propionate (538 mg) and palladium on carbon (5%, 500 mg) and the reaction mixture was treated to afford the title compound (476 mg) as a syrup.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-4811102461fa48348f9815b473e60099
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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