Potassium Carbonate → Ethyl 2-phenoxy-3-[4-[2-(tetrahydropyran-2-yloxy)ethoxy]phenyl]propionate

Participants

Reaction Steps

In a similar manner to that described in Reference example 3(e), a reaction was carried out using ethyl 3-(4-hydroxyphenyl)-2-phenoxypropionate (3.33 g), which is the product of Reference example 4(c), 2-(2-bromoethoxy)tetrahydropyran (7.27 g) and potassium carbonate (6.41 g) in dimethylacetamide and the reaction mixture was treated to afford the desired compound (4.53 g) as a syrup.

Provenance & Evidence