p-Toluenesulfonic acid monohydrate → Ethyl 3-[4-(2-hydroxyethoxy)phenyl]-2-phenoxypropionate

Participants

Reaction Steps

In a similar manner to that described in Reference example 3(f), a reaction was carried out using ethyl 2-phenoxy-3-[4-[2-(tetrahydropyran-2-yloxy)ethoxy]phenyl]propionate (4.53 g), which is the product of Reference example 4(d), and p-toluenesulfonic acid monohydrate (2.70 g) and the reaction mixture was treated to afford the desired compound (3.28 g) as a syrup.

Provenance & Evidence