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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1859959Generated: October 31, 2026

Methanesulfonyl chloride → Ethyl 3-[4-(2-methanesulfonyloxyethoxy)phenyl]-2-phenoxypropionate

https://huagongshe.com/reaction/1859959

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanesulfonyl chlorideHCID 31297—
ReactantEthyl 3-[4-(2-hydroxyethoxy)phenyl]-2-phenoxypropionateHCID 18625939—
SolventTriethylamineHCID 8471—
ProductEthyl 3-[4-(2-methanesulfonyloxyethoxy)phenyl]-2-phenoxypropionateHCID 18625787—

Reaction Steps

In a similar manner to that described in Reference example 3(g), a reaction was carried out using ethyl 3-[4-(2-hydroxyethoxy)phenyl]-2-phenoxypropionate (3.27 g), which is the product of Reference example 4(e), triethylamine (2.07 ml) and methanesulfonyl chloride (0.84 ml) and the reaction mixture was treated to afford the desired compound (4.20 g) as a syrup.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06528525B1
Source datasetuspto-grants-2003_03
ORD IDord-84c6fb28bba44922b1c081fb738b5545
Source noteuspto-grants-2003_03