Potassium Hydroxide → 3-(4-Hydroxyphenyl)-2-(4-isopropylphenoxy)propionic acid

HRID 1859965Notes

Reaction equation

HRID 1859965 reaction equation
OC1C=CC([C:8]([O:19][C:20]2[CH:25]=[CH:24][C:23]([CH:26]([CH3:28])[CH3:27])=[CH:22][CH:21]=2)([C:14](OCC)=O)[C:9]([O:11]CC)=[O:10])=CC=1.[OH-:29].[K+]>>[OH:29][C:20]1[CH:25]=[CH:24][C:23]([CH2:14][CH:8]([O:19][C:20]2[CH:21]=[CH:22][C:23]([CH:26]([CH3:28])[CH3:27])=[CH:24][CH:25]=2)[C:9]([OH:11])=[O:10])=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 18625710Diethyl 2-(4-hydroxyphenyl)-2-(4-isopropylphenoxy)malonate

Product 1

HCID 186256923-(4-Hydroxyphenyl)-2-(4-isopropylphenoxy)propionic acid

Procedure

In a similar manner to that described in Reference example 2(b), a reaction was carried out using diethyl 2-(4-hydroxyphenyl)-2-(4-isopropylphenoxy)malonate (25.2 g), which is the product of Reference example 5(c), and potassium hydroxide (20.0 g) and the reaction mixture was treated to afford, via crystals of 3-(4-hydroxyphenyl)-2-(4-isopropylphenoxy)propionic acid, the desired compound (19.8 g) as a syrup.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-64a76feafb154057bc18710479b7b973
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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