Sodium Azide → HCID 18625722, compound

HRID 1859969Notes

Reaction equation

HRID 1859969 reaction equation
[CH:1]([C:4]1[CH:31]=[CH:30][C:7]([O:8][CH:9]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24]OS(C)(=O)=O)=[CH:18][CH:17]=2)[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[N-:32]=[N+:33]=[N-:34].[Na+]>>[N:32]([CH2:24][CH2:23][O:22][C:19]1[CH:20]=[CH:21][C:16]([CH2:15][CH:9]([O:8][C:7]2[CH:30]=[CH:31][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:5][CH:6]=2)[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:17][CH:18]=1)=[N+:33]=[N-:34]

Participants

3

Reactant 2

HCID 33557Sodium AzideHCID 18625791HCID 18625791, compound

Product 1

HCID 18625722HCID 18625722, compoundYield 91.4%

Procedure

In a similar manner to that described in Reference example 3 (h), a reaction was carried out using ethyl 2-(4-isopropylphenoxy)-3-[4-(2-methanesulfonyloxyethoxy)phenyl]propionate (19.6 g), which is the product of Reference example 5(g), and sodium azide (7.06 g), and the reaction mixture was treated to afford the desired compound (15.8 g) as a syrup.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-d838eb403f57471dae1d2e1e8751181c
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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