Potassium Hydroxide → HCID 18625808, compound

HRID 1859978Notes

Reaction equation

HRID 1859978 reaction equation
[CH3:1][C:2]([CH2:13][CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)(C(OCC)=O)[C:3]([O:5][CH2:6][CH3:7])=[O:4].[OH-].[K+]>>[CH3:1][CH:2]([CH2:13][CH2:14][CH2:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)[C:3]([O:5][CH2:6][CH3:7])=[O:4]

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 18625691HCID 18625691, compound

Product 1

HCID 18625808HCID 18625808, compoundYield 91.1%

Procedure

In a similar manner to that described in Reference example 2(b), a reaction was carried out using diethyl 2-methyl-2-(3-phenylpropyl)malonate (4.63 g) and potassium hydroxide (3.55 g) and the reaction mixture was treated to afford the desired compound (3.18 g) as a syrup.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-e85135ed76e5463395946a5fd9581ae7
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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